We are heading down the final stretch of the 2022 regular season and we already saw some incredible games Saturday in Week 16 (you can check out our grades here and also the latest look at the playoff picture). As we continue to enjoy the holiday weekend with three more games on Christmas Day and the Week 16 finale on Monday night, you won’t want to miss a second of the NFL action,
As we do every week, we’ve collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts as well as additional featured content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff and more.
All NFL odds via Caesars Sportsbook.
Which picks can you make with confidence in Week 16? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up more than $7,000 for $100 players on top-rated NFL picks since its inception.
Buccaneers at Cardinals
Time: Sunday, 8:20 p.m. ET (NBC), stream on fuboTV (try for free)
Open: Buccaneers -3
Current: Buccaneers -7.5
Featured Game | Arizona Cardinals vs. Tampa Bay Buccaneers
“So, the Buccaneers aren’t very good. They blew at 17-point lead to the Bengals last week while Tom Brady turned the ball over on four straight drives. At the same time, the Cardinals are not very good either. Without Kyler Murray, the Cardinals lost to Brett Rypien and the lowly Denver Broncos, 24-15.
“This game is in Arizona, which is bad for the Cardinals. They are 1-12 SU and 3-10 ATS in their last 13 home games, and Trace McSorley is in line to make his first career start with Colt McCoy in concussion protocol. The Buccaneers still have a one-game lead in the NFC South, and I’m just banking on Brady rebounding against a bad team late in the season.” — CBS Sports’ Jordan Dajani on why he is laying the 7.5 points with Tampa Bay against Arizona.
Chargers at Colts
Time: Monday, 8:15 p.m. ET (ESPN), stream on fuboTV (try for free)
Open: Chargers -2.5
Current: Chargers -4.5
Featured Game | Indianapolis Colts vs. Los Angeles Chargers
SportsLine expert R.J. White routinely crushes against-the-spread picks and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He’s also an incredible 22-9-2 on his last 33 against-the-spread picks involving the Chargers, returning $1,193 for $100 bettors. Naturally, you’ll want to know which way he’s leaning with this primetime matchup with Los Angeles. We can tell you he’s leaning Under the total, but he knows a crucial X-factor makes one side of the spread a must-back! To see what that is, go check out SportsLine.