Broncos vs. Cardinals prediction, odds, line, spread: 2022 NFL picks, Week 15 best bets from proven model

    The Denver Broncos (3-10) aim to snap a five-game losing streak when they host the Arizona Cardinals (4-9) on Sunday at Empower Field at Mile High. The Cardinals are looking to snap a three-game losing streak of their own after losing 27-13 to the New England Patriots in their last outing. The Broncos dropped their most recent game to the Kansas City Chiefs 34-28. Both teams will be led by their backup quarterbacks with Kyler Murray (knee) out for the year, and Russell Wilson (concussion) out for this game. Brett Rypien will be starting for the Broncos, and Colt McCoy for the Cardinals. Wide receivers Courtland Sutton (hamstring) and Kendall Hinton (hamstring) are both out for Denver.

    Kickoff is at 4:05 p.m. ET. Denver is favored by 1.5 points in the latest Broncos vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 37. Before making any Cardinals vs. Broncos picks, you’ll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

    The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. 

    The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

    Now, the model has set its sights on Broncos vs. Cardinals and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL betting lines for Cardinals vs. Broncos:

    • Broncos vs. Cardinals spread: Broncos -1.5
    • Broncos vs. Cardinals over/under: 37 points
    • Broncos vs. Cardinals money line: Denver -125, Arizona +105
    • Broncos vs. Cardinals picks: See picks here

    Featured Game | Denver Broncos vs. Arizona Cardinals

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    What you need to know about the Broncos

    It’s rare for a team to be elite on one side of the ball, and then be arguably the worst in the league on the other side of the ball, but that’s exactly what the Broncos have done in 2022. Offensively, Denver ranks dead last in the NFL in points scored per game (14.9) and is sixth worst in total yards per game (315.5). 

    Defensively, the Broncos are allowing 18.3 points per game, the fourth best figure in the league, and 314.3 total yards per game, seventh best in the NFL. Denver will be without its top pass rusher, Dre’Mont Jones, who was placed on injured reserve this week with a hip injury. The Broncos are 5-8 against the spread in 2022.

    What you need to know about the Cardinals

    Meanwhile, the Cardinals came up short against the New England Patriots this past Monday, falling 27-13. QB Colt McCoy had a tough game, throwing one interception. Running back James Conner rushed for 85 yards and a touchdown on 15 carries. 

    Arizona is stumbling into the game with the third most touchdowns allowed in the NFL, having given up 39 on the season. Their defense should get a break on Sunday against the Broncos, who rank dead last in the NFL in points scored per game (14.9) and will be without Wilson and wide receiver Courtland Sutton. Arizona is 6-7 against the spread in 2022.

    How to make Cardinals vs. Broncos picks

    The model has simulated Broncos vs. Cardinals 10,000 times and the results are in. The model is leaning Over on the point total, and it’s also generated a point-spread pick that is hitting in more than 50% of simulations. You can only see the model’s pick at SportsLine.

    So who wins Cardinals vs. Broncos? And which side of the spread hits in more than 50% of simulations? Visit SportsLine now to see which side of the Broncos vs. Cardinals spread you need to jump on Sunday, all from the model that has crushed its NFL picks, and find out.

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